Fmoc-(R)-3-Amino-3-(4-chlorophenyl)-propionic acid

Name: Fmoc-(R)-3-Amino-3-(4-chlorophenyl)-propionic acid
Brand: ChemScene
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CAS No. 479064-92-1
Cat. No. CS-0062192
Purity≥98%
MDL No.MFCD03428036

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Fmoc-(R)-3-Amino-3-(4-chlorophenyl)-propionic acid|CS-0062192

Structure of 479064-92-1

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Description

Fmoc-(R)-3-Amino-3-(4-chlorophenyl)-propionic acid is a chiral building block designed for peptide synthesis, featuring a fluorinated benzyl protecting group and a para-chlorophenyl side chain. This configuration enhances solubility and stability during coupling steps, enabling efficient incorporation into complex peptide sequences under standard conditions.

Application

Fmoc-(R)-3-Amino-3-(4-chlorophenyl)-propionic acid serves as a valuable building block for the synthesis of non-natural amino acids and peptidomimetics. The Fmoc group provides efficient orthogonal protection for primary amines, enabling straightforward solid-phase peptide synthesis. The pendant 4-chlorophenyl moiety offers enhanced hydrophobicity and metabolic stability, while the α-amino acid core facilitates standard coupling reactions. Bench-stable and readily purified by chromatography, this reagent enables reliable incorporation into complex molecular architectures.

General Information

CAS No. 479064-92-1
Cat. No. CS-0062192
Purity ≥98%
MDL No. MFCD03428036
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₄H₂₀ClNO₄
Molecular Weight 421.87
Synonym(s) Fmoc-R-3-Amino-3-(4-chloro-phenyl)-propionic acid
SMILES O=C(O)C[C@H](C1=CC=C(Cl)C=C1)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O

Computational Chemistry Data

TPSA 75.63
LogP 5.3945
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Chloride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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Fmoc-(R)-3-Amino-3-(4-chlorophenyl)-propionic acid

CAS No. 479064-92-1

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