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CS-W001157 4
Total: USD 88.00

(2,3-Difluoro-4-formylphenyl)boronic acid

  • CAS No. 480424-84-8

  • Cat. No. CS-0134554
  • Purity≥97%
  • MDL No.MFCD04039907
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(2,3-Difluoro-4-formylphenyl)boronic acid|CS-0134554

Structure of 480424-84-8

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Description

This boronate moiety integrates a difluorinated aryl scaffold with a formyl handle, enabling efficient coupling in Suzuki-Miyaura transformations and facilitating downstream functionalization. The electron-deficient ring enhances reactivity while maintaining bench stability under standard conditions.

Application

(2,3-Difluoro-4-formylphenyl)boronic acid serves as a versatile building block for Suzuki-Miyaura cross-coupling reactions, enabling efficient construction of biaryl scaffolds under mild conditions. The formyl group provides orthogonal functionality for downstream transformations, including reductive amination or oxime formation, while the difluoro substitution enhances metabolic stability and modulates electronic properties in pharmaceutical intermediates. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step syntheses requiring functional group compatibility and predictable reactivity.

General Information

  • CAS No. 480424-84-8
  • Cat. No. CS-0134554
  • Purity ≥97%
  • MDL No. MFCD04039907
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BF₂O₃
  • Molecular Weight 185.92
  • Synonym(s) 2,3-Difluoro-4-formylphenylboronic acid
  • SMILES OB(C1=CC=C(C=O)C(F)=C1F)O

Computational Chemistry Data

  • TPSA   57.53
  • LogP   -0.5429
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H332-H335
Precautionary Statements : P233-P260-P261-P264-P270-P271-P280-P302+P352

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