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Structure of 4837-20-1
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4-(Difluoromethoxy)benzoic acid features a para-difluoromethoxy group that imparts enhanced lipophilicity and metabolic stability, making it valuable for medicinal chemistry applications. The carboxylic acid functionality enables direct coupling reactions or salt formation, facilitating integration into bioactive molecules under standard conditions.
4-(Difluoromethoxy)benzoic acid serves as a valuable building block in medicinal chemistry, offering a polar, electron-withdrawing difluoromethoxy group ortho to a carboxylic acid. This combination enables enhanced metabolic stability and modulated lipophilicity in API candidates. The compound exhibits good bench stability, facilitates straightforward derivatization via esterification or amide coupling, and demonstrates compatibility with standard coupling protocols in peptide and heterocyclic synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: