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CS-W001157 4
Total: USD 88.00

2-Benzimidazolemethanol

  • CAS No. 4856-97-7

  • Cat. No. CS-0019195
  • Purity≥98%
  • MDL No.MFCD00014560

*For research and further manufacturing use only, not for direct human use.

2-Benzimidazolemethanol|CS-0019195

Structure of 4856-97-7

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General Information

  • CAS No. 4856-97-7
  • Cat. No. CS-0019195
  • Purity ≥98%
  • MDL No. MFCD00014560
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₈N₂O
  • Molecular Weight 148.16
  • Synonym(s) 1H-Benzimidazol-2-ylmethanol; 2-(Hydroxymethyl)benzimidazole
  • SMILES OCC1=NC2=CC=CC=C2N1

Description

2-Benzimidazolemethanol was used in the preparation of 2-(chloromethyl)-1-(methylsulfonyl)benzimidazole via methanesulfonylation. It was also used in the synthesis of 1H-benzimidazol-2-ylmethyl diethyl phosphate.

Application

2-Benzimidazolemethanol serves as a versatile building block in medicinal chemistry, enabling efficient construction of benzimidazole-based scaffolds. Its hydroxymethyl group facilitates straightforward functionalization via oxidation, etherification, or coupling reactions. The molecule exhibits good bench stability and compatibility with common protecting group strategies, making it well-suited for multi-step syntheses and API development workflows.

Synthesis

  • Route1
    • In-stock
      Glycolic acid|CS-W016683
      79-14-1
    • null|null
      95-54-5
    • ~75%
    • In-stock
      2-Benzimidazolemethanol|CS-0019195
      4856-97-7

    References

    • Eom, Young Woo; Oh, Sangtae; Woo, Ho Bum; Ham, Jungyeob; Ahn, Chan Mug; Lee, Seokjoon Bulletin of the Korean Chemical Society, 2013 , vol. 34, # 4 p. 1272 - 1274
  • Route2
    • null|null
      25289-18-3
    • null|null
      95-54-5
    • ~88%
    • In-stock
      2-Benzimidazolemethanol|CS-0019195
      4856-97-7

    References

    • Xia, Zhengqiang; Wei, Qing; Yang, Qi; Qiao, Chengfang; Chen, Sanping; Xie, Gang; Zhang, Guochun; Zhou, Chunsheng; Gao, Shengli CrystEngComm, 2013 , vol. 15, # 1 p. 86 - 99
  • Route3
    • In-stock
      Ethyl hydroxyacetate|CS-W019892
      623-50-7
    • null|null
      95-54-5
    • ~82%
    • In-stock
      2-Benzimidazolemethanol|CS-0019195
      4856-97-7

    References

    • Dekhane, Deepak V.; Pawar, Shivaji S.; Gupta, Sunil V.; Shingare, Murlidhar S.; Thore, Shivaji N. Chinese Chemical Letters, 2010 , vol. 21, # 5 p. 519 - 523

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H315-H319-H332-H335
Precautionary Statements : P260-P261-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P304+P341-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P363-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.91
  • LogP   1.0552
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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