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CS-W001157 4
Total: USD 88.00

4-Quinolinecarboxylic acid

  • CAS No. 486-74-8

  • Cat. No. CS-0008340
  • Molecule weight173.17
  • Purity≥98%
  • MDL No.MFCD00006782

*For research and further manufacturing use only, not for direct human use.

4-Quinolinecarboxylic acid|CS-0008340

Structure of 486-74-8

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General Information

  • CAS No. 486-74-8
  • Cat. No. CS-0008340
  • Purity ≥98%
  • MDL No. MFCD00006782
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₇NO₂
  • Molecular Weight 173.17
  • Synonym(s) Cinchoninic acid; 4-Carboxyquinoline; NSC 13138
  • SMILES O=C(C1=CC=NC2=CC=CC=C12)O

Description

4-Quinolinecarboxylic acid was used in the coupling reaction with diamine linker. A 4-quinolinecarboxylic acid analogue, brequinar sodium was used to inhibit dihydroorotate dehydrogenase and the de novo biosynthesis of pyrimidine.

Application

4-Quinolinecarboxylic acid (CAS 486-74-8) drives coupling reactions with diamine linkers to form functionalized architectures in synthetic chemistry. It enables precise molecular scaffolding. Researchers leverage this scaffold to develop potent inhibitors like brequinar sodium, which targets dihydroorotate dehydrogenase and halts pyrimidine biosynthesis in proliferating cells.

Synthesis

  • Route1
    • null|null
      491-35-0
    • ~86%
    • In-stock
      4-Quinolinecarboxylic acid|CS-0008340
      486-74-8

    References

    • Sakaguchi, Satoshi; Shibamoto, Akihiro; Ishii, Yasutaka Chemical Communications, 2002 , # 2 p. 180 - 181
  • Route2

    References

    • Ainley; King Proceedings of the Royal Society of London, Series B: Biological Sciences, 1938 , vol. 125, p. 60,69
  • Route3
    • null|null
      5632-16-6
    • ~83%
    • In-stock
      4-Quinolinecarboxylic acid|CS-0008340
      486-74-8

    References

    • Zhong, Qi-Di; Xue, Yun-Zhou; Yan, Hong; Song, Xiu-Qing; Zhong, Ru-Gang Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5532 - 5535

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   1.933
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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