1-tert-Butyl 4-methyl 4-hydroxypiperidine-1,4-dicarboxylate

Name: 1-tert-Butyl 4-methyl 4-hydroxypiperidine-1,4-dicarboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 495415-09-3
Cat. No. CS-0038556
Purity≥97%
MDL No.MFCD11845429

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-tert-Butyl 4-methyl 4-hydroxypiperidine-1,4-dicarboxylate|CS-0038556

Structure of 495415-09-3

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Description

1-tert-Butyl 4-methyl 4-hydroxypiperidine-1,4-dicarboxylate features a sterically shielded piperidine core with orthogonal functional handles: a bench-stable hydroxyl group and two ester moieties. This configuration enables selective derivatization in complex molecule assembly, particularly in medicinal chemistry scaffolds requiring controlled polarity and metabolic stability.

Application

1-tert-Butyl 4-methyl 4-hydroxypiperidine-1,4-dicarboxylate serves as a versatile scaffold for the synthesis of piperidine-based building blocks. The hydroxyl group enables selective derivatization via esterification or protection, while the tert-butyl and methyl esters offer orthogonal deprotection options. Its bench-stable nature and compatibility with standard coupling and cyclization protocols facilitate efficient access to complex heterocyclic intermediates in medicinal chemistry and API development.

General Information

CAS No. 495415-09-3
Cat. No. CS-0038556
Purity ≥97%
MDL No. MFCD11845429
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₂H₂₁NO₅
Molecular Weight 259.30
Synonym(s) Methyl 1-Boc-4-hydroxypiperidine-4-carboxylate
SMILES CC(C)(OC(N1CCC(C(OC)=O)(O)CC1)=O)C

Computational Chemistry Data

TPSA 76.07
LogP 0.9214
H_Acceptors 5
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Alcohol

Building Blocks Functional Group Ester

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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1-tert-Butyl 4-methyl 4-hydroxypiperidine-1,4-dicarboxylate

CAS No. 495415-09-3

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