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CS-W001157 4
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5-Fluoropicolinamide

  • CAS No. 499796-71-3

  • Cat. No. CS-W022386
  • Purity≥97%
  • MDL No.MFCD11976463

*For research and further manufacturing use only, not for direct human use.

5-Fluoropicolinamide|CS-W022386

Structure of 499796-71-3

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General Information

  • CAS No. 499796-71-3
  • Cat. No. CS-W022386
  • Purity ≥97%
  • MDL No. MFCD11976463
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅FN₂O
  • Molecular Weight 140.12
  • Synonym(s) 2-Pyridinecarboxamide,5-fluoro
  • SMILES O=C(N)C1=NC=C(F)C=C1

Description

5-Fluoropicolinamide serves as a key heterocyclic building block in medicinal chemistry, featuring a fluorinated pyridine core that enhances metabolic stability and modulates electronic properties. This amide functionality enables direct incorporation into bioactive molecules, facilitating hydrogen bonding interactions in target binding sites. The compound exhibits excellent solubility in common organic solvents and is stable under standard bench conditions.

Application

5-Fluoropicolinamide serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated heterocycles and bioactive molecules. Its pyridine scaffold offers enhanced metabolic stability and modulated basicity, while the amide functionality provides excellent compatibility with standard coupling reactions. The molecule exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis campaigns in API development.

Synthesis

  • Route1

    References

    • Tamura, Masazumi; Wakasugi, Hiroko; Shimizu, Ken-Ichi; Satsuma, Atsushi Chemistry - A European Journal, 2011 , vol. 17, # 41 p. 11428 - 11431

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   55.98
  • LogP   0.3196
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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