NSC 135302

Name: NSC 135302
Brand: ChemScene
Availability: InStock
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CAS No. 500577-99-1
Cat. No. CS-0028247
Purity≥96%
MDL No.MFCD03407440

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HazMat Fee

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The shipment is processed through FedEx Ground under the Limited Quantity option.

Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Structure of 500577-99-1

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Description

4-Amino-3,5-difluorobenzoic acid features a trifunctional core combining an electron-deficient aromatic ring with orthogonal reactive handles. The para-amino group enables conjugation and derivatization, while the meta-fluorine substituents support nucleophilic aromatic substitution. This bench-stable scaffold delivers high compatibility in bioconjugation workflows and serves as a key building block for fluorinated pharmaceutical intermediates and functionalized materials.

Application

4-Amino-3,5-difluorobenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive scaffolds via amide coupling or amidation reactions. The ortho-fluoro groups facilitate nucleophilic aromatic substitution under mild conditions, while the carboxylic acid and amino functionalities offer orthogonal reactivity for sequential functionalization. Bench-stable and readily purified by recrystallization, it functions efficiently in standard peptide and heterocyclic synthesis workflows.

General Information

CAS No. 500577-99-1
Cat. No. CS-0028247
Purity ≥96%
MDL No. MFCD03407440
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₅F₂NO₂
Molecular Weight 173.12
Synonym(s) 4-Amino-3,5-difluorobenzoic acid
SMILES O=C(O)C1=CC(F)=C(N)C(F)=C1

Computational Chemistry Data

TPSA 63.32
LogP 1.2452
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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NSC 135302

CAS No. 500577-99-1

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