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CS-W001157 4
Total: USD 88.00

1-Bromo-5-fluoro-2-methyl-3-nitrobenzene

  • CAS No. 502496-33-5

  • Cat. No. CS-W005372
  • Purity≥97%
  • MDL No.MFCD03094189
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-Bromo-5-fluoro-2-methyl-3-nitrobenzene|CS-W005372

Structure of 502496-33-5

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Description

1-Bromo-5-fluoro-2-methyl-3-nitrobenzene features a trifunctional aromatic core with orthogonal reactivity. The bromo group enables palladium-catalyzed cross-coupling, while the nitro and fluoro substituents provide strong electron-withdrawing effects. This combination facilitates selective functionalization in complex synthesis.

Application

1-Bromo-5-fluoro-2-methyl-3-nitrobenzene serves as a versatile building block in medicinal chemistry and materials synthesis, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The nitro group facilitates downstream reduction and cyclization pathways, while the methyl and fluorine substituents provide steric and electronic modulation. This compound exhibits bench stability and compatibility with standard purification techniques, making it well-suited for multi-step synthesis workflows.

General Information

  • CAS No. 502496-33-5
  • Cat. No. CS-W005372
  • Purity ≥97%
  • MDL No. MFCD03094189
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrFNO₂
  • Molecular Weight 234.02
  • Synonym(s) benzene, 1-bromo-5-fluoro-2-methyl-3-nitro-
  • SMILES O=[N+](C1=C(C)C(Br)=CC(F)=C1)[O-]

Computational Chemistry Data

  • TPSA   43.14
  • LogP   2.80482
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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