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CS-W001157 4
Total: USD 88.00

(E)-2-(4-Fluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

  • CAS No. 504433-86-7

  • Cat. No. CS-W012675
  • Purity≥95%
  • MDL No.MFCD12546189
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

(E)-2-(4-Fluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane|CS-W012675

Structure of 504433-86-7

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Description

(E)-2-(4-Fluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane features a stable boronate ester coupled to an (E)-configured fluoro-substituted styrenyl group. This configuration enhances regioselectivity in Suzuki-Miyaura couplings, enabling efficient C–C bond formation under mild conditions. The tetramethyl substituents confer exceptional bench stability and moisture tolerance, simplifying handling in synthetic workflows.

Application

(E)-2-(4-Fluorostyryl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane serves as a stable, bench-ready boronate building block for Suzuki-Miyaura cross-coupling reactions. The (E)-configured styryl moiety enables stereoselective coupling with aryl and heteroaryl halides, facilitating efficient construction of conjugated biaryl systems. Its tetramethyl-substituted dioxaborolane ring enhances stability and minimizes protodeboronation, while the fluorine substituent offers orthogonal reactivity for downstream functionalization in medicinal chemistry and materials synthesis.

General Information

  • CAS No. 504433-86-7
  • Cat. No. CS-W012675
  • Purity ≥95%
  • MDL No. MFCD12546189
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₈BFO₂
  • Molecular Weight 248.10
  • Synonym(s) 4-Fluoro-Trans-Beta-Styrylboronic Acid Pinacol Ester
  • SMILES CC1(C)C(C)(C)OB(/C=C/C2=CC=C(F)C=C2)O1

Computational Chemistry Data

  • TPSA   18.46
  • LogP   3.4703
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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