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CS-W001157 4
Total: USD 88.00

Homopiperazine

  • CAS No. 505-66-8

  • Cat. No. CS-W007768
  • Purity≥98%
  • MDL No.MFCD00006933

*For research and further manufacturing use only, not for direct human use.

Homopiperazine|CS-W007768

Structure of 505-66-8

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General Information

  • CAS No. 505-66-8
  • Cat. No. CS-W007768
  • Purity ≥98%
  • MDL No. MFCD00006933
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂N₂
  • Molecular Weight 100.17
  • Synonym(s) None
  • SMILES N1CCNCCC1

Description

Homopiperazine delivers a flexible, nitrogen-rich scaffold ideal for medicinal chemistry applications. Featuring two amine-bearing positions separated by a methylene spacer, it integrates readily into bioactive molecules. This structural motif enhances solubility and enables strategic hydrogen bonding in target engagement.

Application

Homopiperazine serves as a versatile bifunctional building block in medicinal chemistry, enabling the construction of complex heterocyclic scaffolds through standard coupling and cyclization protocols. Its inherent stability, favorable solubility, and tolerance to diverse reaction conditions facilitate efficient synthesis of drug candidates and functional intermediates.

Synthesis

  • Route1
    • null|null
      107-15-3
    • null|null
      109-76-2
    • ~%
    • null|null
      110-85-0
    • In-stock
      Homopiperazine|CS-W007768
      505-66-8
    • In-stock
      N1-(2-Aminoethyl)propane-1,3-diamine|CS-0077151
      13531-52-7
    • null|null
      111-40-0

    References

    • DOW GLOBAL TECHNOLOGIES LLC; KING, Stephen W. Patent: WO2012/64483 A1, 2012 ; Location in patent: Page/Page column 18-20 ;
  • Route2

    References

    • Ishiguro; Matsumura Yakugaku Zasshi, 1959 , vol. 79, p. 153,156 Chem.Abstr., 1959 , p. 13163
  • Route3
    • null|null
      5451-44-5
    • ~%
    • In-stock
      Homopiperazine|CS-W007768
      505-66-8

    References

    • McElvain; Bannister Journal of the American Chemical Society, 1954 , vol. 76, p. 1126,1129

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS06
Signal Word : Danger
UN#: 3259
Class : 8
Packing Group : Ⅱ
Hazard Statements : H311-H314-H318
Precautionary Statements : P260-P264-P280-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P305+P351+P338-P361+P364-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   24.06
  • LogP   -0.4307
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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