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Structure of 50650-59-4
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2-Hydroxy-4-(trifluoromethyl)pyridine features a strategically positioned trifluoromethyl group that enhances electron deficiency and metabolic stability, while the hydroxyl moiety enables direct participation in hydrogen bonding and metal coordination. This combination supports efficient integration into pharmaceutical intermediates and functional materials under standard conditions.
2-Hydroxy-4-(trifluoromethyl)pyridine serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine ring due to its activated C2 position. The hydroxyl group facilitates derivatization via etherification or esterification, while the trifluoromethyl moiety imparts enhanced metabolic stability and lipophilicity. Its bench-stable nature and compatibility with standard coupling reactions make it a practical scaffold for synthesizing bioactive heterocycles and API intermediates.
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GHS Pictogram :
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GHS No : GHS05,GHS07
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Signal Word : Danger
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UN#: 1759
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H302-H318
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Precautionary Statements : P264-P270-P280-P330-P501
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Lot numbers can be found on the outside label of a product: