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CS-W001157 4
Total: USD 88.00

L-Hydroxyproline

  • CAS No. 51-35-4

  • Cat. No. CS-W008928
  • Molecule weight131.13
  • Purity≥98%
  • MDL No.MFCD00064320

*For research and further manufacturing use only, not for direct human use.

L-Hydroxyproline|CS-W008928

Structure of 51-35-4

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General Information

  • CAS No. 51-35-4
  • Cat. No. CS-W008928
  • Purity ≥98%
  • MDL No. MFCD00064320
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₉NO₃
  • Molecular Weight 131.13
  • Synonym(s) (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
  • SMILES O=C(O)[C@H](C1)NC[C@@H]1O

Description

Synthesizing chiral ligands for enantioselective aldehyde ethylation, trans-4-Hydroxy-L-proline (CAS 51-35-4) enables stereoselective transformations in asymmetric catalysis and serves as a key precursor in kainoid and echinocandin biosynthesis.

Application

trans-4-Hydroxy-L-proline (CAS 51-35-4) drives collagen biosynthesis by stabilizing triple-helix formation in fibrillar proteins through precise stereochemical positioning. It enhances structural integrity. Researchers rely on this modulator to study extracellular matrix dynamics, validate mass spectrometry protocols, and refine chromatographic separation methods for biomedical applications.

Synthesis

  • Route1
    • L-Proline Enalapril  Impurity|CS-0229432
      147-85-3
    • ~89%
    • In-stock
      L-Hydroxyproline|CS-W008928
      51-35-4

    References

    • Shibasaki; Mori; Ozaki Bioscience, biotechnology, and biochemistry, 2000 , vol. 64, # 4 p. 746 - 750
  • Route2

    References

    • Kurokawa, Natsuko; Ohfune, Yasufumi Journal of the American Chemical Society, 1986 , vol. 108, # 19 p. 6041 - 6043
  • Route3
    • tert-Butyl ((3S,5S)-5-(bromomethyl)-2-oxotetrahydrofuran-3-yl)carbamate|CS-0255703
      104241-30-7
    • ~%
    • In-stock
      L-Hydroxyproline|CS-W008928
      51-35-4

    References

    • Kurokawa, Natsuko; Ohfune, Yasufumi Journal of the American Chemical Society, 1986 , vol. 108, # 19 p. 6041 - 6043

Safety Information

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GHS Pictogram : N/A
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Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   69.56
  • LogP   -1.2062
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   1

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