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Structure of 51411-81-5
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3-Amino-4-iodobenzoic acid features a carboxylic acid group flanked by an amino substituent and a reactive iodine atom at the para position relative to the amine. This arrangement enables direct coupling in cross-coupling reactions, facilitating efficient access to functionalized aromatic scaffolds. The molecule exhibits enhanced solubility in polar solvents and stability under standard bench conditions.
3-Amino-4-iodobenzoic acid serves as a versatile building block for the synthesis of bioactive heterocycles and pharmaceutical intermediates. Its orthogonal functionality—amine, iodine, and carboxylic acid—enables sequential derivatization via Suzuki-Miyaura coupling, amidation, or electrophilic substitution. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for iterative synthetic workflows in medicinal chemistry and process development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: