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CS-W001157 4
Total: USD 88.00

3-Chloro-5-fluoropyridine

  • CAS No. 514797-99-0

  • Cat. No. CS-W021904
  • Purity≥96%
  • MDL No.MFCD05663707

*For research and further manufacturing use only, not for direct human use.

3-Chloro-5-fluoropyridine|CS-W021904

Structure of 514797-99-0

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General Information

  • CAS No. 514797-99-0
  • Cat. No. CS-W021904
  • Purity ≥96%
  • MDL No. MFCD05663707
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃ClFN
  • Molecular Weight 131.54
  • Synonym(s) Pyridine, 3-chloro-5-fluoro- (9CI)
  • SMILES ClC1=CC(=CN=C1)F

Description

3-Chloro-5-fluoropyridine is a heterocyclic building block featuring complementary halogen substituents at adjacent positions on the pyridine ring. This electron-deficient scaffold enables direct functionalization in cross-coupling reactions and serves as a key intermediate in pharmaceutical synthesis. Its bench-stable nature supports reliable handling under standard conditions.

Application

3-Chloro-5-fluoropyridine serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its orthogonal halogen reactivity. The chloro and fluoro substituents offer distinct reaction handles for sequential functionalization, while the pyridine core provides a stable, electron-deficient scaffold suitable for drug-like molecule synthesis. Its bench-stable solid form facilitates handling and purification in standard laboratory workflows.

Synthesis

  • Route1

    References

    • Schlosser, Manfred; Bobbio, Carla European Journal of Organic Chemistry, 2002 , # 24 p. 4174 - 4180
  • Route2
    • 5-Chloro-3-fluoro-2-hydrazinylpyridine|CS-0450321
      248255-70-1
    • ~72%
    • In-stock
      3-Chloro-5-fluoropyridine|CS-W021904
      514797-99-0

    References

    • Bobbio, Carla; Rausis, Thierry; Schlosser, Manfred Chemistry - A European Journal, 2005 , vol. 11, # 6 p. 1903 - 1910
  • Route3

    References

    • Schlosser, Manfred; Bobbio, Carla European Journal of Organic Chemistry, 2002 , # 24 p. 4174 - 4180

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05,GHS07
Signal Word : Danger
UN#: 1325
Class : 4.1
Packing Group : Ⅲ
Hazard Statements : H228-H302-H315-H318-H335
Precautionary Statements : P210-P240-P241-P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   1.8741
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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