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Structure of 515135-65-6
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5-Bromo-2-fluoro-4-methylbenzoic acid features a strategically positioned bromine, fluorine, and methyl group on the aromatic ring, enabling selective functionalization in medicinal chemistry. The carboxylic acid moiety provides a robust anchor for conjugation, while the electron-withdrawing halogens enhance reactivity in cross-coupling transformations under standard conditions.
5-Bromo-2-fluoro-4-methylbenzoic acid serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling direct incorporation into heterocyclic scaffolds via standard coupling reactions. Its ortho-fluoro and meta-bromo substituents provide orthogonal reactivity for palladium-catalyzed cross-coupling, while the carboxylic acid group facilitates amidation, esterification, and derivatization under mild conditions. The methyl group enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified by recrystallization, it functions efficiently in multi-step syntheses requiring precise substitution patterns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: