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CS-W001157 4
Total: USD 88.00

(2-Iodophenyl)methanol

  • CAS No. 5159-41-1

  • Cat. No. CS-W004678
  • Molecule weight234.04
  • Purity≥98%
  • MDL No.MFCD00004610

*For research and further manufacturing use only, not for direct human use.

(2-Iodophenyl)methanol|CS-W004678

Structure of 5159-41-1

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General Information

  • CAS No. 5159-41-1
  • Cat. No. CS-W004678
  • Purity ≥98%
  • MDL No. MFCD00004610
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₇IO
  • Molecular Weight 234.04
  • Synonym(s) None
  • SMILES OCC1=CC=CC=C1I

Description

2-Iodobenzyl alcohol was used in the synthesis of: substituted seven-membered lactones2-[(E)-(1-iodo-2-propenyl)]benzyl alcohol2,3-diphenyl-1-indenone

Application

(2-Iodophenyl)methanol serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl scaffolds. Its iodine substituent facilitates palladium- or nickel-catalyzed coupling with boronic acids, esters, and halides under standard conditions. The benzylic alcohol functionality offers orthogonal reactivity for derivatization, including oxidation to aldehydes or carboxylic acids, and protection as ethers or esters. Bench-stable and readily purified by recrystallization or column chromatography, it supports scalable synthesis in medicinal chemistry and materials development.

Synthesis

  • Route1

    References

    • Yao, Sheng; Gallenkamp, Daniel; Woelfel, Katharina; Lueke, Bettina; Schindler, Michael; Scherkenbeck, Juergen Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 15 p. 4669 - 4678
  • Route2
    • null|null
      99948-46-6
    • ~94%
    • In-stock
      (2-Iodophenyl)methanol|CS-W004678
      5159-41-1

    References

    • Srinivasulu; Satyanarayana; Ravi Kumar Russian Journal of General Chemistry, 2013 , vol. 83, # 12 p. 2419 - 2422 Zh. Obshch. Khim., 2013 , vol. 83, # 12 p. 2419 - 2422,4
  • Route3

    References

    • Lee, Jaeyoung; Ryu, Taekyu; Park, Sangjune; Lee, Phil Ho Journal of Organic Chemistry, 2012 , vol. 77, # 10 p. 4821 - 4825

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.7835
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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