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CS-W001157 4
Total: USD 88.00

o-Iodobenzoic acid

  • CAS No. 88-67-5

  • Cat. No. CS-D0909
  • Molecule weight248.02
  • Purity≥98%
  • MDL No.MFCD00002419

*For research and further manufacturing use only, not for direct human use.

o-Iodobenzoic acid|CS-D0909

Structure of 88-67-5

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General Information

  • CAS No. 88-67-5
  • Cat. No. CS-D0909
  • Purity ≥98%
  • MDL No. MFCD00002419
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅IO₂
  • Molecular Weight 248.02
  • Synonym(s) 2-Iodobenzoic acid
  • SMILES O=C(O)C1=CC=CC=C1I

Description

PEG21 is a polymer of ethylene glycol subunits with two terminal hydroxyl groups. The hydroxyl groups can react to further derivatize the compound. The hydrophilic PEG linker increases the water solubility of the compound in aqueous media. The water solubility properties of the PEG chain are enhanced with longer PEG chains.

Application

o-Iodobenzoic acid serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient C–C and C–heteroatom bond formation under standard Suzuki, Stille, and Negishi conditions. The ortho-iodo group exhibits high reactivity while maintaining bench stability, facilitating straightforward purification and compatibility with diverse functional groups. Its utility is well-documented in the synthesis of biaryl scaffolds and heterocyclic frameworks relevant to pharmaceutical and agrochemical development.

Synthesis

  • Route1
    • null|null
      118-92-3
    • ~79%
    • In-stock
      o-Iodobenzoic acid|CS-D0909
      88-67-5

    References

    • Gorlushko; Filimonov; Semenishcheva; Krasnokutskaya; Tret'yakov; Go, Bong Seong; Hwang, Ho Yun; Cha, Eun Hye; Chi, Ki-Whan Russian Journal of Organic Chemistry, 2008 , vol. 44, # 8 p. 1243 - 1244
  • Route2
    • null|null
      1059625-67-0
    • ~90%
    • In-stock
      o-Iodobenzoic acid|CS-D0909
      88-67-5

    References

    • Filimonov, Victor D.; Trusova, Marina; Postnikov, Pavel; Krasnokutskaya, Elena A.; Lee, Young Min; Hwang, Ho Yun; Kim, Hyunuk; Chi, Ki-Whan Organic Letters, 2008 , vol. 10, # 18 p. 3961 - 3964
  • Route3
    • null|null
      201230-82-2
    • null|null
      7169-58-6
    • ~74%
    • In-stock
      o-Iodobenzoic acid|CS-D0909
      88-67-5

    References

    • Nagira, Kazuhiko; Kikukawa, Kiyoshi; Wada, Fumio; Matsuda, Tsutomu Journal of Organic Chemistry, 1980 , vol. 45, # 12 p. 2365 - 2368

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.9894
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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