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CS-W001157 4
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Tetrahydropyran-2-carboxylic acid

  • CAS No. 51673-83-7

  • Cat. No. CS-W001872
  • Molecule weight130.14
  • Purity≥95%
  • MDL No.MFCD07779239

*For research and further manufacturing use only, not for direct human use.

Tetrahydropyran-2-carboxylic acid|CS-W001872

Structure of 51673-83-7

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General Information

  • CAS No. 51673-83-7
  • Cat. No. CS-W001872
  • Purity ≥95%
  • MDL No. MFCD07779239
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₀O₃
  • Molecular Weight 130.14
  • Synonym(s) Tetrahydro-2H-pyran-2-carboxylic acid
  • SMILES OC(=O)C1CCCCO1

Description

Tetrahydropyran-2-carboxylic acid serves as a valuable synthetic intermediate featuring a stable heterocyclic ring and a carboxylic acid handle. This bench-stable compound integrates readily into diverse coupling reactions, enabling efficient access to functionalized building blocks for medicinal chemistry and materials synthesis.

Application

Tetrahydropyran-2-carboxylic acid serves as a versatile building block in synthetic organic chemistry, enabling efficient access to oxygen-containing heterocycles and functionalized intermediates. Its carboxylic acid group facilitates direct coupling reactions and derivatization, while the tetrahydropyran ring provides metabolic stability and structural rigidity. This compound exhibits good bench stability, moderate solubility in common organic solvents, and compatibility with standard protecting group strategies, making it valuable for medicinal chemistry campaigns and multistep synthesis workflows.

Synthesis

  • Route1

    References

    • Enholm, Eric J.; Schreier, Jeffrey A. Journal of Heterocyclic Chemistry, 1995 , vol. 32, # 1 p. 109 - 112
  • Route2
    • Sodium 3,4-dihydro-2H-pyran-2-carboxylate|CS-0557019
      16698-52-5
    • ~86%
    • In-stock
      Tetrahydropyran-2-carboxylic acid|CS-W001872
      51673-83-7

    References

    • Alvarez-Wright, Maria Teresa; Satici, Hikmet; Eliel, Ernest L.; White, Peter S. Journal of the Indian Chemical Society, 1999 , vol. 76, # 11-12 p. 617 - 629
  • Route3
    • 2-Ethynyloxane|CS-0216262
      76928-53-5
    • ~%
    • In-stock
      Tetrahydropyran-2-carboxylic acid|CS-W001872
      51673-83-7

    References

    • Mukai, Chisato; Sugimoto, Yu-Ichi; Ikeda, Yoshitaka; Hanaoka, Miyoji Tetrahedron, 1998 , vol. 54, # 5-6 p. 823 - 850

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 3265
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302-H315-H318-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   0.6401
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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