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CS-W001157 4
Total: USD 88.00

1-Methanesulfonylpiperidine-4-carboxylic acid

  • CAS No. 280772-00-1

  • Cat. No. CS-0046828
  • Purity≥97%
  • MDL No.None
  • HazMat Fee +

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    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-Methanesulfonylpiperidine-4-carboxylic acid|CS-0046828

Structure of 280772-00-1

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Description

1-Methanesulfonylpiperidine-4-carboxylic acid features a rigid piperidine core functionalized with both a methanesulfonyl group and a carboxylic acid, enabling dual reactivity. This combination supports efficient conjugation in medicinal chemistry scaffolds and facilitates solubility modulation in peptide derivatization workflows.

Application

1-Methanesulfonylpiperidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling and functional group manipulation. The methanesulfonyl group enhances solubility and metabolic stability, while the carboxylic acid facilitates amide bond formation and conjugation. Its bench-stable nature and compatibility with common reaction conditions make it suitable for scalable, reproducible workflows in API development.

General Information

  • CAS No. 280772-00-1
  • Cat. No. CS-0046828
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₃NO₄S
  • Molecular Weight 207.25
  • Synonym(s) 1-(Methylsulfonyl)piperidine-4-carboxylic acid
  • SMILES O=S(N1CCC(C(O)=O)CC1)(C)=O

Computational Chemistry Data

  • TPSA   74.68
  • LogP   -0.2574
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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