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Structure of 518044-41-2
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Mal-PEG4-acid features a maleimide group conjugated to a four-ether-unit polyethylene glycol chain terminating in a carboxylic acid. This structure enables site-specific bioconjugation via thiol-Michael addition, while the PEG spacer enhances solubility and reduces aggregation. The terminal acid facilitates further coupling reactions, such as amide formation, enabling modular linker design for probes, therapeutics, or biomaterials.
Mal-PEG4-acid serves as a versatile bifunctional linker for conjugation and bioconjugation applications. The maleimide group enables efficient, site-specific thiol-ene addition with cysteine residues, while the terminal carboxylic acid facilitates amide coupling or further functionalization. PEG4 provides enhanced solubility and reduced aggregation, improving stability in aqueous environments. This reagent is well-suited for the synthesis of antibody-drug conjugates, protein-polymer hybrids, and targeted delivery systems.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: