5-Amino-2-ethoxypyridine

Name: 5-Amino-2-ethoxypyridine
Brand: ChemScene
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CAS No. 52025-34-0
Cat. No. CS-0195502
Purity≥98%
MDL No.MFCD01646194

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 52025-34-0

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Description

5-Amino-2-ethoxypyridine features a strategically positioned amino group that enhances electron density at the pyridine ring, enabling efficient coupling in cross-coupling reactions. The ethoxy substituent improves solubility and modulates reactivity under standard conditions. This compound serves as a key building block for functionalized heterocycles in medicinal chemistry and materials science applications.

Application

5-Amino-2-ethoxypyridine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based scaffolds through standard coupling and functionalization reactions. Its amino group facilitates electrophilic substitution and transition-metal-catalyzed cross-couplings, while the ethoxy substituent offers moderate stability and ease of manipulation under common reaction conditions. The compound demonstrates good bench stability and compatibility with diverse synthetic workflows, making it suitable for the construction of bioactive heterocycles and API intermediates.

General Information

CAS No. 52025-34-0
Cat. No. CS-0195502
Purity ≥98%
MDL No. MFCD01646194
Storage RT, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₁₀N₂O
Molecular Weight 138.17
Synonym(s) 2-Ethoxy-5-aminopyridine
SMILES CCOC1=NC=C(C=C1)N

Computational Chemistry Data

TPSA 48.14
LogP 1.0625
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 2

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Other Classifications

Building Blocks Functional Group Ether

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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5-Amino-2-ethoxypyridine

CAS No. 52025-34-0

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