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3-Hydroxy-2-naphthonitrile

  • CAS No. 52449-77-1

  • Cat. No. CS-0155683
  • Purity≥98%
  • MDL No.MFCD17012306
  • HazMat Fee +

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    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

3-Hydroxy-2-naphthonitrile|CS-0155683

Structure of 52449-77-1

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Description

3-Hydroxy-2-naphthonitrile features a naphthalene scaffold bearing a hydroxyl group at the 3-position and a cyano group at the 2-position, enabling its use in heterocyclic synthesis. The adjacent electron-withdrawing nitrile enhances reactivity at the aromatic ring, while the phenolic OH supports hydrogen bonding and metal coordination. This structure facilitates incorporation into functionalized scaffolds for pharmaceutical intermediates and advanced materials.

Application

3-Hydroxy-2-naphthonitrile serves as a versatile building block in synthetic organic chemistry, enabling access to functionalized naphthalene scaffolds through established transformations. Its ortho-hydroxynitrile motif facilitates regioselective derivatization, including cyclizations and metal-catalyzed coupling reactions. The compound exhibits good bench stability and compatibility with common protecting group strategies, making it well-suited for iterative synthesis in medicinal chemistry and materials development.

General Information

  • CAS No. 52449-77-1
  • Cat. No. CS-0155683
  • Purity ≥98%
  • MDL No. MFCD17012306
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₇NO
  • Molecular Weight 169.18
  • Synonym(s) 2-Cyano-3-hydroxynaphthalene
  • SMILES C1=CC2=CC(=C(C=C2C=C1)O)C#N

Computational Chemistry Data

  • TPSA   44.02
  • LogP   2.41708
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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