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Structure of 52570-33-9
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Methyl 3-iodo-2-methylbenzoate is a bench-stable, electron-deficient aromatic ester featuring a strategically positioned iodine atom at the meta position relative to the methyl ester group. This configuration enables direct coupling in palladium-catalyzed cross-coupling reactions without requiring additional protecting groups. The ortho-methyl substituent enhances regioselectivity and provides steric guidance during transformation.
Methyl 3-iodo-2-methylbenzoate serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient access to substituted biaryl and heteroaryl architectures. The iodide group facilitates reliable Suzuki, Stille, and Negishi couplings, while the methyl and ester functionalities provide orthogonal handles for further derivatization. Bench-stable and readily purified by flash chromatography, it supports scalable synthesis in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: