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5-Chloropentan-1-ol

  • CAS No. 5259-98-3

  • Cat. No. CS-0095410
  • Molecule weight122.59
  • Purity≥95%
  • MDL No.MFCD00039556

*For research and further manufacturing use only, not for direct human use.

5-Chloropentan-1-ol|CS-0095410

Structure of 5259-98-3

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General Information

  • CAS No. 5259-98-3
  • Cat. No. CS-0095410
  • Purity ≥95%
  • MDL No. MFCD00039556
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁ClO
  • Molecular Weight 122.59
  • Synonym(s) None
  • SMILES ClCCCCCO

Description

5-Chloropentan-1-ol is a versatile chlorinated diol featuring a terminal hydroxyl group and a chlorine substituent at the γ-position. This structure enables efficient functionalization in synthetic transformations, particularly in nucleophilic substitutions and cyclization reactions. The molecule exhibits favorable solubility in polar organic solvents and maintains stability under standard bench conditions, facilitating its use in multi-step synthesis and polymer modification workflows.

Application

5-Chloropentan-1-ol serves as a versatile bifunctional building block, enabling efficient synthesis of heterocyclic scaffolds and polymer intermediates. The primary alcohol facilitates derivatization via esterification or ether formation, while the terminal chloride supports nucleophilic substitution reactions under mild conditions. Its bench-stable nature and compatibility with common protecting group strategies make it well-suited for multi-step synthetic sequences in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • Hanack; Fuchs; Collins Journal of the American Chemical Society, 1983 , vol. 105, # 12 p. 4008 - 4017
  • Route2

    References

    • Guan, Jian; Kyle, Dennis E.; Gerena, Lucia; Zhang, Quan; Milhous, Wilbur K.; Lin, Ai J. Journal of Medicinal Chemistry, 2002 , vol. 45, # 13 p. 2741 - 2748
  • Route3

    References

    • Khusnutdinov; Shchadneva; Burangulova; Muslimov; Dzhemilev Russian Journal of Organic Chemistry, 2006 , vol. 42, # 11 p. 1615 - 1621

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.3878
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   4

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