Furan-2-sulfonyl chloride

Name: Furan-2-sulfonyl chloride
Brand: ChemScene
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CAS No. 52665-48-2
Cat. No. CS-0435084
Purity≥98%
MDL No.MFCD06658968

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 52665-48-2

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Description

Furan-2-sulfonyl chloride is a reactive sulfonyl chloride derivative featuring a furan ring, enabling direct incorporation into heterocyclic scaffolds. The sulfonyl chloride group facilitates efficient coupling reactions under mild conditions, delivering stable sulfonamide linkages. This reagent offers high chemoselectivity and compatibility with diverse functional groups, making it valuable for synthesizing bioactive molecules and advanced materials.

Application

Furan-2-sulfonyl chloride serves as a versatile sulfonylating agent for the direct introduction of sulfonamide groups into nucleophilic substrates, including amines and alcohols. Its reactivity is well-documented in synthetic workflows involving heterocyclic systems, offering high functional group tolerance and ease of purification. The furan ring imparts moderate stability under standard bench conditions while enabling downstream transformations through the heteroaromatic scaffold. This compound facilitates rapid access to sulfonamide-containing building blocks relevant to medicinal chemistry and agrochemical research.

General Information

CAS No. 52665-48-2
Cat. No. CS-0435084
Purity ≥98%
MDL No. MFCD06658968
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₃ClO₃S
Molecular Weight 166.58
Synonym(s) Furane-2-sulfonylchloride
SMILES O=S(C1=CC=CO1)(Cl)=O

Computational Chemistry Data

TPSA 47.28
LogP 1.2071
H_Acceptors 3
H_Donors 0
Rotatable_Bonds 1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS05
Signal Word : Danger	UN#: 3265
Class : 8	Packing Group : Ⅱ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Furan compounds

Key Words

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Furan-2-sulfonyl chloride

CAS No. 52665-48-2

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