6-Chloropyrimidin-4-amine

Name: 6-Chloropyrimidin-4-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 5305-59-9
Cat. No. CS-W001884
Purity≥97%
MDL No.MFCD00053576

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 5305-59-9

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Description

6-Chloropyrimidin-4-amine serves as a critical heterocyclic building block in medicinal chemistry, featuring a chlorine atom at the 6-position and an amino group at the 4-position. This combination enables direct coupling in cross-coupling reactions and facilitates downstream derivatization in drug discovery pipelines. The molecule exhibits good stability under standard conditions and integrates readily into diverse molecular architectures.

Application

6-Chloropyrimidin-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds through nucleophilic substitution and transition-metal-catalyzed coupling reactions. Its moderate reactivity and bench stability facilitate straightforward functionalization at the C6 position, while the amino group supports further derivatization via acylation or alkylation. This compound functions effectively in the synthesis of kinase inhibitors and other bioactive heterocycles, offering predictable regiochemistry and compatibility with standard purification methods.

General Information

CAS No. 5305-59-9
Cat. No. CS-W001884
Purity ≥97%
MDL No. MFCD00053576
Storage -20°C, sealed storage, away from moisture and light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₄ClN₃
Molecular Weight 129.55
Synonym(s) 6-chloro-4-aminopyrimidine
SMILES Nc1ncnc(c1)Cl

Computational Chemistry Data

TPSA 51.8
LogP 0.7122
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

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6-Chloropyrimidin-4-amine

CAS No. 5305-59-9

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