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Structure of 5326-38-5
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1-Iodo-2-methyl-4-nitrobenzene features a reactive iodine atom flanked by an electron-withdrawing nitro group and a methyl substituent, enabling efficient cross-coupling reactions under standard conditions. This ortho-substituted aryl iodide exhibits enhanced stability and predictable reactivity in palladium-catalyzed transformations, making it a reliable building block for complex molecular architectures in medicinal chemistry and materials science.
1-Iodo-2-methyl-4-nitrobenzene serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and substituted aromatic scaffolds. The iodide group facilitates reliable coupling under standard Pd(0)-catalyzed conditions, while the ortho-methyl and para-nitro substituents provide predictable electronic and steric control. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319-H335
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Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: