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CS-W001157 4
Total: USD 88.00

1-Iodo-2-methyl-4-nitrobenzene

  • CAS No. 5326-38-5

  • Cat. No. CS-W012470
  • Purity≥98%
  • MDL No.MFCD00051517
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-Iodo-2-methyl-4-nitrobenzene|CS-W012470

Structure of 5326-38-5

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Description

1-Iodo-2-methyl-4-nitrobenzene features a reactive iodine atom flanked by an electron-withdrawing nitro group and a methyl substituent, enabling efficient cross-coupling reactions under standard conditions. This ortho-substituted aryl iodide exhibits enhanced stability and predictable reactivity in palladium-catalyzed transformations, making it a reliable building block for complex molecular architectures in medicinal chemistry and materials science.

Application

1-Iodo-2-methyl-4-nitrobenzene serves as a versatile building block in transition-metal-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and substituted aromatic scaffolds. The iodide group facilitates reliable coupling under standard Pd(0)-catalyzed conditions, while the ortho-methyl and para-nitro substituents provide predictable electronic and steric control. Its bench-stable crystalline form simplifies handling and purification, making it well-suited for iterative synthesis in medicinal chemistry and materials science applications.

General Information

  • CAS No. 5326-38-5
  • Cat. No. CS-W012470
  • Purity ≥98%
  • MDL No. MFCD00051517
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆INO₂
  • Molecular Weight 263.03
  • Synonym(s) 2-Iodo-5-nitrotoluene
  • SMILES CC1=C(I)C=CC(=C1)[N+]([O-])=O

Computational Chemistry Data

  • TPSA   43.14
  • LogP   2.50782
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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