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CS-W001157 4
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Thiazol-2-ylmethanamine dihydrochloride

  • CAS No. 53332-78-8

  • Cat. No. CS-0053668
  • Purity≥95%
  • MDL No.MFCD09817422

*For research and further manufacturing use only, not for direct human use.

Thiazol-2-ylmethanamine dihydrochloride|CS-0053668

Structure of 53332-78-8

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General Information

  • CAS No. 53332-78-8
  • Cat. No. CS-0053668
  • Purity ≥95%
  • MDL No. MFCD09817422
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₈Cl₂N₂S
  • Molecular Weight 187.09
  • Synonym(s) 2-(Aminomethyl)thiazole Dihydrochloride
  • SMILES NCC1=NC=CS1.Cl.Cl

Description

Thiazol-2-ylmethanamine (dihydrochloride) features a thiazole ring fused to a primary amine group, delivering a potent heterocyclic scaffold for medicinal chemistry. This bench-stable derivative enhances solubility and reactivity in synthetic workflows, enabling efficient coupling reactions. The dihydrochloride salt form ensures improved handling and storage stability.

Application

Thiazol-2-ylmethanamine (dihydrochloride) serves as a versatile building block for thiazole-containing pharmaceuticals and agrochemicals. The compound enables direct incorporation of the thiazolylmethyl scaffold into diverse molecular architectures via amine functionalization, including amidation, alkylation, and reductive amination. Its dihydrochloride salt form enhances solubility and bench stability, facilitating handling in standard synthetic workflows. The thiazole ring provides robust metabolic resistance and favorable pharmacophore properties, making it valuable in medicinal chemistry campaigns targeting kinase inhibitors and antimicrobial agents.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.4454
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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