Thiazol-2-ylmethanamine dihydrochloride

Name: Thiazol-2-ylmethanamine dihydrochloride
Brand: ChemScene
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CAS No. 53332-78-8
Cat. No. CS-0053668
Purity≥97%
MDL No.None

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Thiazol-2-ylmethanamine dihydrochloride|CS-0053668

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Description

Thiazol-2-ylmethanamine (dihydrochloride) features a thiazole ring fused to a primary amine group, delivering a potent heterocyclic scaffold for medicinal chemistry. This bench-stable derivative enhances solubility and reactivity in synthetic workflows, enabling efficient coupling reactions. The dihydrochloride salt form ensures improved handling and storage stability.

Application

Thiazol-2-ylmethanamine (dihydrochloride) serves as a versatile building block for thiazole-containing pharmaceuticals and agrochemicals. The compound enables direct incorporation of the thiazolylmethyl scaffold into diverse molecular architectures via amine functionalization, including amidation, alkylation, and reductive amination. Its dihydrochloride salt form enhances solubility and bench stability, facilitating handling in standard synthetic workflows. The thiazole ring provides robust metabolic resistance and favorable pharmacophore properties, making it valuable in medicinal chemistry campaigns targeting kinase inhibitors and antimicrobial agents.

General Information

CAS No. 53332-78-8
Cat. No. CS-0053668
Purity ≥97%
MDL No. None
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₈Cl₂N₂S
Molecular Weight 187.09
Synonym(s) 2-(Aminomethyl)thiazole Dihydrochloride
SMILES NCC1=NC=CS1.Cl.Cl

Computational Chemistry Data

TPSA 38.91
LogP 1.4454
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Thiazole compounds

Key Words

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Thiazol-2-ylmethanamine dihydrochloride

CAS No. 53332-78-8

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