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Structure of 5335-40-0
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3-(Methylsulphonyl)benzenesulphonyl chloride features a sulfonamide chloride group flanked by an electron-withdrawing methylsulfonyl substituent, enabling selective acylation of nucleophiles under mild conditions. This bench-stable reagent integrates cleanly into synthetic workflows requiring high functional group tolerance and controlled reactivity.
3-(Methylsulphonyl)benzenesulphonyl chloride serves as a versatile sulfonylating agent for the efficient introduction of a bulky, electron-withdrawing sulfonyl group into aromatic and heteroaromatic systems. Its reactivity enables direct functionalization of nucleophiles such as amines and alcohols under mild conditions, offering excellent bench stability and straightforward purification. The molecule functions effectively in the synthesis of sulfonamide-based building blocks and contributes to the construction of pharmaceutically relevant scaffolds through orthogonal transformation pathways.
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GHS Pictogram :
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GHS No : GHS05
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Signal Word : Danger
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UN#: 3261
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H314
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Precautionary Statements : P260-P280-P301+P330+P331-P304+P340
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Lot numbers can be found on the outside label of a product: