6-Iodopyrimidin-4-amine

Name: 6-Iodopyrimidin-4-amine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 53557-69-0
Cat. No. CS-W022505
Purity≥97%
MDL No.MFCD11109819

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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Description

6-Iodopyrimidin-4-amine is a bench-stable heterocyclic building block featuring a reactive iodide at the 6-position and a nucleophilic amine at the 4-position. This dual functionality enables efficient cross-coupling and derivatization in medicinal chemistry, particularly in the synthesis of kinase inhibitors and nucleoside analogs under standard conditions.

Application

6-Iodopyrimidin-4-amine serves as a versatile building block for the synthesis of pyrimidine-based pharmaceuticals and agrochemicals. Its iodine substituent enables palladium-catalyzed cross-coupling reactions, while the amine group facilitates further functionalization via acylation, alkylation, or cyclization. The compound exhibits excellent bench stability and compatibility with standard synthetic workflows, making it ideal for modular library construction and medicinal chemistry applications.

General Information

CAS No. 53557-69-0
Cat. No. CS-W022505
Purity ≥97%
MDL No. MFCD11109819
Storage -20°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₄IN₃
Molecular Weight 221.00
Synonym(s) 4-Amino-6-iodopyrimidine
SMILES NC1=NC=NC(=C1)I

Computational Chemistry Data

TPSA 51.8
LogP 0.6634
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Iodide

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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6-Iodopyrimidin-4-amine

CAS No. 53557-69-0

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