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CS-W001157 4
Total: USD 88.00

1-Tosylpropan-2-one

  • CAS No. 5366-49-4

  • Cat. No. CS-W015001
  • Purity≥98%
  • MDL No.MFCD00026240

*For research and further manufacturing use only, not for direct human use.

1-Tosylpropan-2-one|CS-W015001

Structure of 5366-49-4

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General Information

  • CAS No. 5366-49-4
  • Cat. No. CS-W015001
  • Purity ≥98%
  • MDL No. MFCD00026240
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₂O₃S
  • Molecular Weight 212.26
  • Synonym(s) p-Toluenesulphonylacetone
  • SMILES CC(CS(=O)(C1=CC=C(C)C=C1)=O)=O

Description

1-Tosylpropan-2-one features a tosyl group attached to a propan-2-one scaffold, delivering a stable, electron-deficient ketone with enhanced solubility in organic media. This configuration enables efficient conjugate additions and Michael reactions under mild conditions, serving as a key intermediate in synthetic pathways requiring controlled electrophilicity and site-selective functionalization.

Synthesis

  • Route1
    • null|null
      824-79-3
    • null|null
      78-95-5
    • ~98%
    • In-stock
      1-Tosylpropan-2-one|CS-W015001
      5366-49-4

    References

    • Organic and Biomolecular Chemistry, , vol. 2, # 23 p. 3510 - 3517
  • Route2
    • null|null
      824-79-3
    • null|null
      598-31-2
    • ~96%
    • In-stock
      1-Tosylpropan-2-one|CS-W015001
      5366-49-4

    References

    • Tetrahedron Letters, , vol. 47, # 23 p. 3853 - 3856
  • Route3
    • null|null
      824-79-3
    • null|null
      67-64-1
    • ~85%
    • In-stock
      1-Tosylpropan-2-one|CS-W015001
      5366-49-4

    References

    • Tetrahedron Letters, , vol. 47, # 25 p. 4197 - 4199

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

  • TPSA   51.21
  • LogP   1.35772
  • H_Acceptors   3
  • H_Donors   0
  • Rotatable_Bonds   3

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