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CS-W001157 4
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3-Amino-1H-pyrazol-5-ol

  • CAS No. 53666-79-8

  • Cat. No. CS-0166925
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

3-Amino-1H-pyrazol-5-ol|CS-0166925

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General Information

  • CAS No. 53666-79-8
  • Cat. No. CS-0166925
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₅N₃O
  • Molecular Weight 99.09
  • Synonym(s) 5-amino-1,2-dihydro-3H-pyrazol-3-one
  • SMILES OC1=CC(N)=NN1

Description

3-Amino-1H-pyrazol-5-ol features a dual functional group architecture—amino and hydroxyl—positioned at adjacent ring carbons, enabling robust hydrogen bonding and enhanced solubility in polar solvents. This scaffold integrates readily into heterocyclic libraries, serving as a key building block for bioactive compound synthesis under standard conditions.

Application

3-Amino-1H-pyrazol-5-ol serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles through standard coupling and cyclization reactions. Its dual functionality—amine and phenolic hydroxyl—facilitates efficient derivatization, orthogonally protected transformations, and integration into pharmaceutically relevant scaffolds. The compound exhibits good bench stability and is amenable to purification via recrystallization or chromatography, supporting reliable use in multi-step syntheses.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   74.93
  • LogP   -0.3025
  • H_Acceptors   3
  • H_Donors   3
  • Rotatable_Bonds   0

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