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Structure of 536747-87-2
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This chiral pyrrolidine derivative features a bench-stable tert-butyl carbamate protecting group and two fluorine atoms at the C4 position, enhancing metabolic stability and modulating electronic properties. The difluoropyrrolidine scaffold integrates readily into peptide-based scaffolds, enabling access to constrained bioactive motifs with improved membrane permeability and target affinity.
(R)-1-(tert-Butoxycarbonyl)-4,4-difluoropyrrolidine-2-carboxylic acid serves as a conformationally constrained, fluorinated proline analog enabling precise stereocontrol in peptide synthesis. The difluoropyrrolidine core enhances metabolic stability and modulates backbone rigidity, while the Boc group permits straightforward deprotection and coupling. This building block exhibits excellent bench stability, tolerance to diverse reaction conditions, and facilitates the construction of bioactive peptidomimetics and macrocyclic scaffolds in medicinal chemistry workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: