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Structure of 5369-19-7
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3-(tert-Butyl)aniline features a sterically hindered tert-butyl group positioned meta to the amino functionality, enhancing stability and reducing unwanted side reactions. This electron-donating substituent modulates reactivity in coupling processes and facilitates handling under standard bench conditions. The compound serves as a robust building block for functionalized aromatic scaffolds in pharmaceutical and materials synthesis.
3-(tert-Butyl)aniline serves as a valuable building block in medicinal chemistry and materials science, offering enhanced solubility and steric bulk due to the tert-butyl group. It functions as a versatile precursor in amide coupling, electrophilic aromatic substitution, and transition-metal-catalyzed cross-coupling reactions. The compound exhibits excellent bench stability and facilitates purification via standard chromatographic methods, making it well-suited for iterative synthesis workflows in API development and functional material design.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: