2-(4-Bromo-2,6-difluorophenyl)acetic acid

Name: 2-(4-Bromo-2,6-difluorophenyl)acetic acid
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 537033-54-8
Cat. No. CS-0060185
Purity≥97%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-(4-Bromo-2,6-difluorophenyl)acetic acid|CS-0060185

Structure of 537033-54-8

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Description

This acetic acid derivative features a 4-bromo-2,6-difluorophenyl moiety that imparts enhanced electronic and steric control. The ortho-fluorine substituents improve metabolic stability, while the bromine enables facile cross-coupling transformations. The carboxylic acid group facilitates direct conjugation or derivatization under standard conditions. This structure serves as a key intermediate in the synthesis of bioactive molecules requiring halogenated aromatic frameworks.

Application

2-(4-Bromo-2,6-difluorophenyl)acetic acid serves as a versatile building block for pharmaceutical intermediates, enabling efficient construction of bioactive heterocycles and substituted aryl scaffolds. Its bromo and difluoro substituents provide orthogonal reactivity for palladium-catalyzed cross-coupling and enhanced metabolic stability. The carboxylic acid group facilitates direct derivatization or salt formation, offering improved solubility and purification advantages in synthetic workflows.

General Information

CAS No. 537033-54-8
Cat. No. CS-0060185
Purity ≥97%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅BrF₂O₂
Molecular Weight 251.02
Synonym(s) 4-Bromo-2,6-difluorophenylaceticacid
SMILES C1=C(C=C(C(=C1F)CC(=O)O)F)Br

Computational Chemistry Data

TPSA 37.3
LogP 2.3544
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 2

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-(4-Bromo-2,6-difluorophenyl)acetic acid

CAS No. 537033-54-8

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