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Structure of 5381-25-9
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1-Benzothiophene-3-carboxylic acid features a rigid heteroaromatic core fused with a carboxylic acid group at the 3-position, enabling direct integration into bioactive molecules. The electron-deficient benzothiophene scaffold enhances π-stacking interactions in target binding, while the acidic functionality facilitates derivatization via amide or ester formation. This compound exhibits excellent stability under standard bench conditions and serves as a key building block in medicinal chemistry and materials science applications.
1-Benzothiophene-3-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to biologically relevant scaffolds. Its carboxylic acid functionality facilitates direct derivatization via amide, ester, or acyl chloride formation, while the fused benzothiophene core provides structural rigidity and favorable pharmacophore characteristics. Bench-stable and readily purified by recrystallization, it functions reliably in standard coupling protocols and transition metal-catalyzed transformations.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: