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CS-W001157 4
Total: USD 88.00

1-Benzothiophene-3-carboxylic acid

  • CAS No. 5381-25-9

  • Cat. No. CS-W008166
  • Purity≥98%
  • MDL No.MFCD01846406
  • HazMat Fee +

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    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

1-Benzothiophene-3-carboxylic acid|CS-W008166

Structure of 5381-25-9

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Description

1-Benzothiophene-3-carboxylic acid features a rigid heteroaromatic core fused with a carboxylic acid group at the 3-position, enabling direct integration into bioactive molecules. The electron-deficient benzothiophene scaffold enhances π-stacking interactions in target binding, while the acidic functionality facilitates derivatization via amide or ester formation. This compound exhibits excellent stability under standard bench conditions and serves as a key building block in medicinal chemistry and materials science applications.

Application

1-Benzothiophene-3-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to biologically relevant scaffolds. Its carboxylic acid functionality facilitates direct derivatization via amide, ester, or acyl chloride formation, while the fused benzothiophene core provides structural rigidity and favorable pharmacophore characteristics. Bench-stable and readily purified by recrystallization, it functions reliably in standard coupling protocols and transition metal-catalyzed transformations.

General Information

  • CAS No. 5381-25-9
  • Cat. No. CS-W008166
  • Purity ≥98%
  • MDL No. MFCD01846406
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₆O₂S
  • Molecular Weight 178.21
  • Synonym(s) 3-CARBOXYLIC ACID BENZOTHIOPHENE
  • SMILES S1C2=C(C(=C1)C(=O)O)C=CC=C2

Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.5995
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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