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Structure of 54136-23-1
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5-Fluoro-2,3,3-trimethyl-3H-indole features a sterically hindered indole core with a fluorine substituent at the 5-position, enhancing electron deficiency and metabolic stability. This bench-stable scaffold integrates readily into bioactive molecules, serving as a key building block for pharmaceutical intermediates and functionalized heterocycles in medicinal chemistry.
5-Fluoro-2,3,3-trimethyl-3H-indole serves as a valuable building block in medicinal chemistry, offering a sterically hindered, electron-deficient indole core. Its fluorinated aromatic ring enhances metabolic stability and modulates electronic properties, while the trimethyl substitution pattern provides steric protection and facilitates purification. The compound functions effectively in C–H functionalization, Suzuki-Miyaura coupling, and heterocycle elaboration, enabling efficient access to complex scaffolds relevant to pharmaceutical development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: