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CS-W001157 4
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1-(2-Fluoroethyl)piperazine

  • CAS No. 541505-04-8

  • Cat. No. CS-0106300
  • Molecule weight132.18
  • Purity≥95%
  • MDL No.MFCD14584708

*For research and further manufacturing use only, not for direct human use.

1-(2-Fluoroethyl)piperazine|CS-0106300

Structure of 541505-04-8

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General Information

  • CAS No. 541505-04-8
  • Cat. No. CS-0106300
  • Purity ≥95%
  • MDL No. MFCD14584708
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃FN₂
  • Molecular Weight 132.18
  • Synonym(s) Piperazine, 1-(2-fluoroethyl)- (9CI)
  • SMILES FCCN1CCNCC1

Description

1-(2-Fluoroethyl)piperazine is a fluorinated piperazine derivative featuring a reactive ethyl linker. This compound integrates a fluorine atom at the β-position, enhancing metabolic stability and enabling selective bioconjugation. The molecule combines lipophilic character with polar nitrogen sites, facilitating membrane permeability and hydrogen bonding. It serves as a key building block in medicinal chemistry for targeted probe development and kinase inhibitor scaffolds.

Application

1-(2-Fluoroethyl)piperazine serves as a versatile building block in medicinal chemistry, enabling the introduction of both amine and fluorinated alkyl functionalities in a single entity. Its reactivity facilitates nucleophilic substitution and coupling reactions, supporting the synthesis of targeted heterocyclic scaffolds and bioactive molecules. The molecule exhibits good bench stability and compatibility with common functional groups, making it suitable for iterative synthesis and process development.

Synthesis

  • Route1
    • null|null
      762-49-2
    • N-Boc-piperazine Olaparib Impurity|CS-0214004
      57260-71-6
    • ~10%
    • In-stock
      1-(2-Fluoroethyl)piperazine|CS-0106300
      541505-04-8

    References

    • ELI LILLY AND COMPANY Patent: WO2007/127763 A2, 2007 ; Location in patent: Page/Page column 40-41 ;
  • Route2
    • tert-Butyl 4-(2-fluoroethyl)piperazine-1-carboxylate|CS-0109760
      184042-58-8
    • ~%
    • In-stock
      1-(2-Fluoroethyl)piperazine|CS-0106300
      541505-04-8

    References

    • Kuntz, Kevin; Uehling, David Edward; Waterson, Alex Gregory; Emmitte, Kyle Allen; Stevens, Kirk; Shotwell, John Brad; Smith, Stephon Cornell; Nailor, Kristen E.; Salovich, James M.; Wilson, Brian John; Cheung, Mui; Mook, Robert Anthony; Baum, Erich W.; Moorthy, Ganesh Patent: US2008/300242 A1, 2008 ; Location in patent: Page/Page column 118-119 ; US 20080300242 A1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05,GHS07
Signal Word : Danger
UN#: 2920
Class : 8,3
Packing Group : Ⅱ
Hazard Statements : H226-H302-H315-H318-H335
Precautionary Statements : P210-P261-P280

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Computational Chemistry Data

  • TPSA   15.27
  • LogP   -0.1389
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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