5-Chloro-2-methylpyrimidine

Name: 5-Chloro-2-methylpyrimidine
Brand: ChemScene
Availability: InStock
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CAS No. 54198-89-9
Cat. No. CS-D1091
Purity≥98%
MDL No.MFCD10574686

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 54198-89-9

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Description

5-Chloro-2-methylpyrimidine serves as a key heterocyclic scaffold in medicinal chemistry, featuring a chlorine atom at the 5-position and a methyl group at the 2-position. This electronic configuration enhances reactivity in nucleophilic substitution processes, enabling efficient coupling with diverse amines and thiols. The molecule exhibits good stability under standard bench conditions and demonstrates favorable solubility in common organic solvents, facilitating its integration into synthetic workflows for pharmaceutical intermediates and functional materials.

Application

5-Chloro-2-methylpyrimidine serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds through palladium-catalyzed cross-coupling and nucleophilic substitution reactions. Its chloro group at the C5 position exhibits high reactivity toward amines, thiols, and organometallic reagents, while the methyl substituent at C2 enhances regioselectivity and metabolic stability. The compound demonstrates excellent bench stability and compatibility with standard synthetic workflows, facilitating rapid diversification in API discovery programs.

General Information

CAS No. 54198-89-9
Cat. No. CS-D1091
Purity ≥98%
MDL No. MFCD10574686
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₅H₅ClN₂
Molecular Weight 128.56
Synonym(s) Pyrimidine, 5-chloro-2-methyl- (7CI,9CI)
SMILES CC1=NC=C(Cl)C=N1

Computational Chemistry Data

TPSA 25.78
LogP 1.43842
H_Acceptors 2
H_Donors 0
Rotatable_Bonds 0

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Other Classifications

Building Blocks Skeleton Aromatic heterocycle compounds Pyrimidine compounds

Key Words

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5-Chloro-2-methylpyrimidine

CAS No. 54198-89-9

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