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Structure of 5423-54-1
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1,5-Naphthyridin-4-ol features a fused bicyclic core with a phenolic hydroxyl group at the 4-position, conferring enhanced hydrogen-bonding capacity and planar rigidity. This structural motif enables strong π-stacking interactions and serves as a key scaffold in bioactive heterocycles. The compound exhibits bench-stable behavior under standard conditions and demonstrates favorable solubility in polar organic solvents, facilitating its integration into synthetic workflows for medicinal chemistry and materials applications.
1,5-Naphthyridin-4-ol serves as a versatile heterocyclic building block in medicinal chemistry, enabling efficient access to bioactive scaffolds through established functionalization pathways. Its stability under standard reaction conditions and compatibility with common coupling protocols facilitate downstream derivatization. The hydroxyl group provides a handle for selective transformations, while the electron-deficient naphthyridine core supports diverse metal-catalyzed cross-couplings and electrophilic substitutions.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: