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Structure of 54326-16-8
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5-Chloropyrimidin-2(1H)-one is a bench-stable heterocyclic building block featuring a chlorine substituent at the 5-position and a lactam carbonyl at the 2-position. This electron-deficient scaffold integrates readily into medicinal chemistry campaigns, enabling direct coupling in cross-coupling reactions or nucleophilic substitution pathways. The molecule's solubility profile supports efficient handling under standard conditions.
5-Chloropyrimidin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling efficient construction of pyrimidine-based scaffolds. Its chlorine substituent at the 5-position facilitates nucleophilic substitution reactions, allowing straightforward functionalization under mild conditions. The compound exhibits good bench stability and compatibility with diverse reaction conditions, making it valuable for synthesizing heterocyclic intermediates, kinase inhibitors, and other bioactive molecules through standard coupling protocols.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: