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Structure of 5454-82-0
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Cyclobutylmethanamine hydrochloride is a bench-stable, moisture-tolerant amine derivative featuring a constrained cyclobutyl ring fused to a methylene linker. This rigid scaffold imparts enhanced metabolic stability and favorable lipophilicity, enabling efficient integration into bioactive molecule design. The hydrochloride salt ensures high solubility in aqueous systems and simplifies handling in synthetic workflows.
Cyclobutylmethanamine hydrochloride serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive scaffolds through amine functionalization. Its cyclobutylmethyl motif provides enhanced metabolic stability and conformational rigidity compared to linear analogs. The hydrochloride salt ensures excellent bench stability, ease of handling, and straightforward purification. It participates reliably in reductive amination, acylation, and coupling reactions, facilitating efficient access to diverse heterocyclic and peptide-like architectures in lead optimization campaigns.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: