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Structure of 5467-58-3
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1-Bromo-4-methoxynaphthalene features a bromine atom at the 1-position and a methoxy group at the 4-position of the naphthalene core. This substitution pattern enhances regioselectivity in palladium-catalyzed cross-coupling reactions. The compound exhibits excellent bench stability and solubility in common organic solvents, enabling efficient integration into synthetic sequences for pharmaceutical intermediates and functional materials.
1-Bromo-4-methoxynaphthalene serves as a versatile building block in cross-coupling reactions, enabling efficient construction of biaryl and functionalized naphthalene scaffolds. The bromine atom facilitates palladium-catalyzed coupling with boronic acids, esters, and organozinc reagents under standard conditions. The methoxy group provides electronic modulation and enhances solubility, while the compound exhibits good bench stability and is readily purified by flash chromatography or recrystallization.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: