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Structure of 54675-23-9
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6-Bromo-4-hydroxyquinolin-2(1H)-one features a brominated quinolinone core with a strategically positioned hydroxyl group, enabling direct functionalization in cross-coupling and derivatization workflows. The electron-deficient framework supports efficient transition metal catalysis, while the bench-stable structure facilitates handling under standard conditions.
6-Bromo-4-hydroxyquinolin-2(1H)-one serves as a versatile building block for the synthesis of substituted quinolones, enabling direct functionalization at the C6 position via palladium-catalyzed cross-coupling reactions. The hydroxyl group provides a handle for derivatization or protection, while the bromine substituent offers high reactivity in Suzuki, Stille, and Negishi coupling protocols. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for medicinal chemistry campaigns and API intermediate development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: