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Structure of 54773-20-5
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1,3-Dichloro-5-(trifluoromethyl)benzene features a trifluoromethyl group that imparts enhanced electron-withdrawal and metabolic stability. The ortho-chlorine substituents enable selective functionalization in cross-coupling reactions, while the molecule's bench-stable nature simplifies handling in synthetic workflows.
1,3-Dichloro-5-(trifluoromethyl)benzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient introduction of electron-withdrawing trifluoromethyl and halogen functionalities. Its stability under standard reaction conditions and compatibility with palladium-catalyzed cross-coupling reactions facilitate the construction of complex aromatic scaffolds. The molecule functions effectively in Suzuki-Miyaura, Stille, and Negishi couplings, offering predictable reactivity and straightforward purification.
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GHS No : GHS02,GHS05
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Signal Word : Danger
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UN#: 1760
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Class : 8
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Packing Group : Ⅲ
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Hazard Statements : H226-H314-H318
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Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501
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Lot numbers can be found on the outside label of a product: