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Structure of 54811-50-6
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2-Iodo-6-methylbenzoic acid features a sterically hindered aromatic core with complementary iodine and methyl substituents positioned ortho to the carboxylic acid group. This arrangement enables efficient cross-coupling reactions while maintaining stability under standard conditions. The electron-deficient aryl iodide integrates readily into complex molecular architectures, offering a reliable handle for C–C bond formation in synthetic workflows.
2-Iodo-6-methylbenzoic acid serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient C–C bond formation in the synthesis of substituted biaryls and functionalized aromatic systems. The iodo group exhibits high reactivity under standard Suzuki, Stille, and Negishi conditions, while the carboxylic acid and methyl groups provide orthogonal handles for further derivatization. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step synthetic sequences targeting complex pharmaceutical intermediates and agrochemical scaffolds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
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Lot numbers can be found on the outside label of a product: