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Structure of 55557-52-3
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3-Chloropyrazine-2-carbonitrile features a fused heterocyclic core with complementary electron-withdrawing groups, enabling efficient coupling in cross-coupling reactions. The chloro and cyano functionalities offer orthogonal reactivity for modular synthesis of functionalized pyrazine derivatives under standard conditions.
3-Chloropyrazine-2-carbonitrile serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyrazine core via nucleophilic substitution. Its chloro group exhibits high reactivity toward amines, thiols, and alcohols under mild conditions, facilitating rapid diversification of heterocyclic scaffolds. The nitrile functionality provides additional handle for transformation, including hydrolysis or reduction, while maintaining compatibility with common protecting groups. Bench-stable and readily purified by crystallization, it supports scalable synthesis of kinase inhibitors and other nitrogen-containing bioactive compounds.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: