AE-ITU dihydrobromide

Name: AE-ITU dihydrobromide
Brand: ChemScene
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CAS No. 56-10-0
Cat. No. CS-0143720
Molecule weight281.01
Purity≥98%
MDL No.MFCD00037011

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Structure of 56-10-0

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General Information

CAS No. 56-10-0
Cat. No. CS-0143720
Purity ≥98%
MDL No. MFCD00037011
Storage 4°C, sealed storage, away from moisture
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₃H₁₁Br₂N₃S
Molecular Weight 281.01
Synonym(s) 2-(2-Aminoethyl)-2-thiopseudourea Dihydrobromide;2-(2-Aminoethyl)Isothiourea Dihydrobromide;AET
SMILES NC(SCCN)=N.[H]Br.[H]Br

Description

Blocking all NOS isoforms with high affinity, 2-(2-Aminoethyl)isothiourea dihydrobromide (CAS 56-10-0) exhibits potent inhibition of human nNOS (Ki 1.8 μM), eNOS (Ki 2.1 μM), and iNOS (Ki 0.59 μM) in enzymatic assays.

Application

2-(2-Aminoethyl)isothiourea dihydrobromide (CAS 56-10-0) inhibits nitric oxide synthase by selectively targeting the enzyme’s active site, disrupting NO production in endothelial and neuronal cells. This suppression alters vascular tone and neuroinflammatory signaling. Researchers leverage this mechanism to study pathological NO overproduction in septic shock and chronic inflammation models.

Synthesis

Route1
- In-stock
  
  2576-47-8
- 17356-08-0
- ~%
- In-stock
  
  56-10-0
References
- Journal of Organic Chemistry USSR (English Translation), , vol. 27, # 5 p. 776 - 779 Zhurnal Organicheskoi Khimii, , vol. 27, # 5 p. 900 - 904

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 75.89
LogP 0.72757
H_Acceptors 3
H_Donors 3
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Thioether

Building Blocks Functional Group Amidine

Key Words

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AE-ITU dihydrobromide

CAS No. 56-10-0

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